Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1

7 Jun 2017

Abstract excerpt

ABSTRACT The st imulator of in terferon (IFN) g enes (STING) is a broad antimicrobial factor that restricts herpes simplex virus (HSV) by activating type I interferon and proinflammatory responses upon sensing of foreign DNA. UL46 is one of the most abundant tegument proteins of HSV-1, but a well-established function has yet to be found. We found that the HSV-1 UL46 protein interacts with and colocalizes with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to interferon and immune responses
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28592536
DOI: 10.1128/jvi.00535-17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1PMID 28592536Read ↗

HSV Replication: Triggering and Repressing STING FunctionalitySemantic proximity Read ↗

Herpes simplex virus 1 encodes a STING antagonist that can be therapeutically targetedSemantic proximity Read ↗

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesvirusesSemantic proximity Read ↗

Molecular and spatial mechanisms governing STING signallingSemantic proximity Read ↗

STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infectionSemantic proximity Read ↗

Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus InfectionSemantic proximity Read ↗

Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesisSemantic proximity Read ↗

RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 InfectionSemantic proximity Read ↗

Host factors associated with either VP16 or VP16‐induced complex differentially affect HSV‐1 lytic infectionSemantic proximity Read ↗

IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone ModificationsSemantic proximity Read ↗

Membrane traffic governs the STING inflammatory signallingSemantic proximity Read ↗

Function and regulation of cGAS-STING signaling in infectious diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.