Article

Mitochondrial competence determines responses to metabolic interventions during aging

2026-05-17

Abstract excerpt

Cellular responses to metabolic interventions vary across physiological contexts, but the basis for this variability remains unclear. Here, we show that mitochondrial competence determines whether cells can engage adaptive metabolic states that support survival during aging. Using 4-methylbenzoic acid (4-MBA), identified as a lifespan-extending compound, as a perturbation probe, we find that modulation of Target o...

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Identifiers and source

Literature Corpus work: 5e35df16-fad6-5318-a764-526407c17827
DOI: 10.64898/2026.05.17.725785

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