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The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling

23 Jan 2014

Abstract excerpt

Cellular and organ metabolism affects organismal lifespan. Aging is characterized by increased risks for metabolic disorders, with age-associated degenerative diseases exhibiting varying degrees of mitochondrial dysfunction. The traditional view of the role of mitochondria generated reactive oxygen species (ROS) in cellular aging, assumed to be causative and simply detrimental for a long time now, is in need of...

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PMID: 24452454
DOI: 10.1152/ajpendo.00665.2013

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