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Mitochondrial Energetics and Therapeutics

1 Jan 2010

Abstract excerpt

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic diseases, cancer, and aging. All these clinical manifestations arise from the central role of bioenergetics in cell biology. Although genetic therapies are maturing as the rules of bioenergetic genetics are clarified, metabolic therapies have been ineffectual. This failure results from our limited appreciation of the role of...

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PMID: 20078222
DOI: 10.1146/annurev.pathol.4.110807.092314

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