Article

Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma

2019-09-20

Abstract excerpt

Identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has been hampered by inappropriately tailored in vitro assays of drug response. Therefore, using a pulse model that closely recapitulates the in vivo pharmacokinetics of platinum therapy, we profiled cisplatin-induced signalling, DNA damage and apoptotic responses across a panel of lung adenoc...

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Literature Corpus work: 5e33573e-a0d1-52e6-bd9e-9570e24c8d5b
DOI: 10.1101/775924

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