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Article

Single cell resolution in vivo imaging of DNA damage following PARP inhibition.

Scientific reports - 18 May 2015

Yang Katherine S, Kohler Rainer H, Landon Matthieu, Giedt Randy, Weissleder Ralph

Abstract excerpt

Targeting DNA repair pathways is a powerful strategy to treat cancers. To gauge efficacy in vivo, typical response markers include late stage effects such as tumor shrinkage, progression free survival, or invasive repeat biopsies. These approaches are often difficult to answer critical questions such as how a given drug affects single cell populations as a function of dose and time, distance from microvessels or...

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Identifiers

PMID: 25984718
DOI: 10.1038/srep10129
PMCID: PMC4434991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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