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Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer

20 Dec 2024

Abstract excerpt

BACKGROUND: correlates with a poor prognosis in non-small cell lung cancer (NSCLC) and, in non-transformed cells, p21 promotes quiescence after replication stress. We tested whether NSCLC cells enter p21-dependent quiescence and if this is advantageous to NSCLC cells. METHODS: Through analysis of patient data and quantitative, single-cell, timelapse imaging of genetically-engineered NSCLC reporter cell lines we...

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PMID: 39706988
DOI: 10.1038/s41416-024-02928-9

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