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High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan.

Cell reports - 22 Oct 2024

Gao Arwen W, El Alam Gaby, Zhu Yunyun, Li Weisha, Sulc Jonathan, Li Xiaoxu, Katsyuba Elena, Li Terytty Y, Overmyer Katherine A, Lalou Amelia, Mouchiroud Laurent, Sleiman Maroun Bou, Cornaglia Matteo, Morel Jean-David, Houtkooper Riekelt H, Coon Joshua J, Auwerx Johan

Abstract excerpt

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. elegans recombinant inbred advanced intercross lines (RIAILs). We assessed molecular profiles-transcriptome, proteome, and lipidome-and life-history traits,...

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PMID: 39368088
DOI: 10.1016/j.celrep.2024.114836

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