Article

Harnessing ALDH1A2 vulnerability in T-cell acute lymphoblastic leukemia

2025-03-14

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with limited therapeutic options, particularly in the relapsed/refractory (R/R) setting. Unlike other hematological malignancies, which benefit from targeted immunotherapies, T-ALL remains reliant on chemotherapy, leading to poor outcomes in R/R cases. Identifying novel therapeutic vulnerabilities is crucial to improving the outcom...

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Literature Corpus work: 5e269fbf-1ba3-52b5-a06b-d83910ad6ed8
DOI: 10.1101/2025.03.11.642712

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