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Article

ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

22 Jun 2022

Abstract excerpt

Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies and found that ALDH1A1 could induce cancers via the maintenance of cancer stem cell properties, modification of...

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PMID: 35814382
DOI: 10.3389/fonc.2022.918778

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