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The Expanding Role of Cancer Stem Cell Marker ALDH1A3 in Cancer and Beyond

13 Jan 2023

Abstract excerpt

Aldehyde dehydrogenase 1A3 (ALDH1A3) is one of 19 ALDH enzymes expressed in humans, and it is critical in the production of hormone receptor ligand retinoic acid (RA). We review the role of ALDH1A3 in normal physiology, its identification as a cancer stem cell marker, and its modes of action in cancer and other diseases. ALDH1A3 is often over-expressed in cancer and promotes tumor growth, metastasis, and...

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PMID: 36672441
DOI: 10.3390/cancers15020492

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