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Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia

14 May 2025

Abstract excerpt

BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a relatively rare hematological malignancy, characterized by the uncontrolled proliferation of immature T lymphoblasts and associated with a generally unfavorable prognosis. Our previous research has demonstrated that decreased mitochondrial activity is associated with the aggressiveness of T-ALL tumors. However, the mechanisms underlying this phenomenon...

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PMID: 40369632
DOI: 10.1186/s12967-025-06423-4

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