The role of mutant IDH1 and IDH2 inhibitors in the treatment of acute myeloid leukemia.

Abstract excerpt

For decades, researchers have looked into the pathophysiology of acute myeloid leukemia (AML). With the advances in molecular techniques, the two-hit hypothesis was replaced by a multi-hit model, which also emphasizes the importance of aberrant epigenetic regulation in the pathogenesis of AML. IDH1 and IDH2 are two isoforms of isocitrate dehydrogenase that perform crucial roles in cellular metabolism. Somatic...

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• Aminopyridines
• Enzyme Inhibitors
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Leukemic
• Isocitrate Dehydrogenase