Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL.

Journal of hematology & oncology - 3 May 2021

Simonin Mathieu, Schmidt Aline, Bontoux Christophe, Dourthe Marie-Émilie, Lengliné Etienne, Andrieu Guillaume P, Lhermitte Ludovic, Graux Carlos, Grardel Nathalie, Cayuela Jean-Michel, Huguet Françoise, Arnoux Isabelle, Ducassou Stéphane, Macintyre Elizabeth, Gandemer Virginie, Dombret Hervé, Petit Arnaud, Ifrah Norbert, Baruchel André, Boissel Nicolas, Asnafi Vahid

Abstract excerpt

IDH1 and IDH2 mutations (IDH1/2Mut) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due to the recent development of specific IDH1/2Mut inhibitors. In T-cell acute lymphoblastic leukemia (T-ALL), their incidence and prognostic implications remain poorly reported. Our targeted next-generation sequencing approach...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Isocitrate Dehydrogenase

Share to Mutation

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Prognosis

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 33941203
DOI: 10.1186/s13045-021-01068-4
PMCID: PMC8091755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL.PMID 33941203Read ↗

Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study.Semantic proximity Read ↗

IDH1/2 mutations in acute myeloid leukemiaSemantic proximity Read ↗

Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML.Semantic proximity Read ↗

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.Semantic proximity Read ↗

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value.Semantic proximity Read ↗

Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups.Semantic proximity Read ↗

Genetic characterization of acute myeloid leukemia patients with mutations in IDH1/2 genes.Semantic proximity Read ↗

Prevalence and Prognostic Role of IDH Mutations in Acute Myeloid Leukemia: Results of the GIMEMA AML1516 ProtocolSemantic proximity Read ↗

Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML.Semantic proximity Read ↗

Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia.Semantic proximity Read ↗

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations.Semantic proximity Read ↗

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.