Article

The Effects of Clonal Heterogeneity on Cancer Immunosurveillance

2023-01-17

Abstract excerpt

Intratumor heterogeneity (ITH) is associated with tumor progression in several clinical and experimental settings and contributes to therapeutic resistance. Its relation to cancer immunosurveillance is complex. Clonally heterogeneous tumors are associated with decreased immunosurveillance and are less responsive to immune checkpoint inhibition, but the mechanistic basis underlying these observations remains unclea...

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Literature Corpus work: 5e1ebd23-cedf-51b8-9a68-db85a96ad05f
DOI: 10.1146/annurev-cancerbio-061521-101910

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