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Article

Subclonal landscape of cancer drives resistance to immune therapy

1 Jan 2022

Abstract excerpt

Tumor mutation burden (TMB) is often used as a biomarker for immunogenicity and prerequisite for immune checkpoint inhibitor (ICI) therapy. However, it is becoming increasingly evident that not all tumors with high TMB respond to ICIs as expected. It has been shown that the ability of T-cells to infiltrate the tumor microenvironment and elicit a specific immune response is dependent not only on the TMB, but also...

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Identifiers

PMID: 35007928
DOI: 10.1016/j.ctarc.2021.100507

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