Article
Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance.
Cancer cell - 13 Apr 2020
Marusyk Andriy, Janiszewska Michalina, Polyak Kornelia
Abstract excerpt
Advances in our understanding of molecular mechanisms of tumorigenesis have translated into knowledge-based therapies directed against specific oncogenic signaling targets. These therapies often induce dramatic responses in susceptible tumors. Unfortunately, most advanced cancers, including those with robust initial responses, eventually acquire resistance to targeted therapies and relapse. Even though...
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