Article

Deletion of the Creatine Transporter in dopaminergic neurons leads to hyperactivity in mice

2018-04-02

Abstract excerpt

Creatine (Cr) is required for proper neuronal function, as evidenced by the intellectual disability and epileptic phenotype seen in patients with cerebral Cr deficiency syndromes (CCDS). In addition, attention-deficit hyperactivity disorder (ADHD) is a frequent co-morbidity of Cr transporter (Crt) deficiency, the leading cause of CCDS. While the effects of the loss of Cr in the whole brain is clear, it is unknown...

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Literature Corpus work: 5deee3e4-7161-51ba-9300-8d689e1cc4d4
DOI: 10.1101/293563

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