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Article

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism.

Scientific reports - 15 Jan 2021

Duran-Trio Lara, Fernandes-Pires Gabriella, Simicic Dunja, Grosse Jocelyn, Roux-Petronelli Clothilde, Bruce Stephen J, Binz Pierre-Alain, Sandi Carmen, Cudalbu Cristina, Braissant Olivier

Abstract excerpt

Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifically taken up by the transporter SLC6A8. Deficit in the endogenous synthesis or in the transport leads to Cerebral Creatine Deficiency Syndromes (CCDS). CCDS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33452333
DOI: 10.1038/s41598-020-80824-x
PMCID: PMC7810893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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