Article

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

2020-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifically taken up by the transporter SLC6A8. Deficit in the endogenous synthesis or in the transport leads to Cerebral Creatine Deficiency Syndro...

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Literature Corpus work: d85ccc86-94e2-5872-abb3-50a62091c8ed
DOI: 10.1101/2020.08.11.246330

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