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Dodecyl Creatine Ester Improves Cognitive Function and Identifies Drivers of Creatine Deficiency

2022-11-04

Abstract excerpt

Creatine transporter deficiency prevents creatine uptake into the brain, leading to mental retardation. To better understand the pathophysiology, this study focuses on the identification of biomarkers related to cognitive improvement in a Slc6a8 knockout mouse model (Slc6a8/y) engineered to mimic the clinical features of CTD patients which have low brain creatine content. Shotgun proteomics analysis of 4,035 prote...

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Literature Corpus work
190057f2-864d-513b-944d-188bee91ed36
DOI
10.1101/2022.11.03.514982
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Dodecyl Creatine Ester Improves Cognitive Function and Identifies Drivers of Creatine DeficiencyDOI 10.1101/2022.11.03.514982
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