Article

Creatine transporter deficient rat model show motor dysfunction, cerebellar alterations and muscle creatine deficiency without muscle atrophy

2021-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Creatine (Cr) is a nitrogenous organic acid and plays roles as fast phosphate energy buffer to replenish ATP, osmolyte, antioxidant, neuromodulator, and as a compound with anabolic and ergogenic properties in muscle. Cr is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifically taken up by the transporter SLC6A8. Loss-of-function mutations in the genes enco...

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Literature Corpus work: 3fd02e9b-f3c9-5097-9343-8ca25b617678
DOI: 10.1101/2021.10.12.464080

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