Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.

Genes, brain, and behavior - 1 Jul 2018

Udobi K C, Kokenge A N, Hautman E R, Ullio G, Coene J, Williams M T, Vorhees C V, Mabondzo A, Skelton M R

Abstract excerpt

Creatine transporter (CrT; SLC6A8) deficiency (CTD) is an X-linked disorder characterized by severe cognitive deficits, impairments in language and an absence of brain creatine (Cr). In a previous study, we generated floxed Slc6a8 (Slc6a8 flox ) mice to create ubiquitous Slc6a8 knockout (Slc6a8-/y ) mice. Slc6a8-/y mice lacked whole body Cr and exhibited cognitive deficits. While Slc6a8-/y mice have a similar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Diseases, Metabolic, Inborn
Share to Cognitive Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Creatine

Share to Learning

Share to Maze Learning

Share to Memory Disorders

Share to X-Linked Intellectual Disability

Source

Open in PubMed Open full text

Identifiers

PMID: 29384270
DOI: 10.1111/gbb.12461
PMCID: PMC6696915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.PMID 29384270Read ↗

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene <i>Slc6a8</i>Semantic proximity Read ↗

A mouse model of a patient derived P544L mutation in the Slc6a8 gene shows hypoactivity and cognitive deficits.Semantic proximity Read ↗

Dodecyl Creatine Ester Improves Cognitive Function and Identifies Drivers of Creatine DeficiencySemantic proximity Read ↗

The Role of Preclinical Models in Creatine Transporter Deficiency: Neurobiological Mechanisms, Biomarkers and Therapeutic DevelopmentSemantic proximity Read ↗

A novel mouse model of creatine transporter deficiencySemantic proximity Read ↗

A novel mouse model of creatine transporter deficiencySemantic proximity Read ↗

Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficitsSemantic proximity Read ↗

Creatine transporter deficient rat model show motor dysfunction, cerebellar alterations and muscle creatine deficiency without muscle atrophySemantic proximity Read ↗

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism.Semantic proximity Read ↗

A mouse model for creatine transporter deficiency reveals early onset cognitive impairment and neuropathology associated with brain agingSemantic proximity Read ↗

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolismSemantic proximity Read ↗

Intellectual Disability and Brain Creatine Deficit: Phenotyping of the Genetic Mouse Model for GAMT Deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.