Article

Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene <i>Slc6a8</i>

2017-09-29

Abstract excerpt

Creatine transporter (CrT; SLC6A8) deficiency (CTD) is an X-linked disorder characterized by severe cognitive deficits, impairments in language, and an absence of brain creatine (Cr). In a previous study, we generated floxed Slc6a8 (Slc6a8 flox ) mice to create ubiquitous Slc6a8 knockout (Slc6a8 -/y ) mice. Slc6a8 -/y mice lacked whole body Cr and exhibited cognitive deficits. While Slc6a8 -/y mice have...

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Literature Corpus work: 1ef92186-d8c2-5433-bbf8-6feca0495be2
DOI: 10.1101/196063

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