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Article

Targeting fetal hemoglobin expression to treat β hemoglobinopathies

3 Apr 2022

Abstract excerpt

Introduction Sickle cell disease and β thalassemia are the principal β hemoglobinopathies. The complex pathophysiology of sickle cell disease is initiated by sickle hemoglobin polymerization. In β thalassemia, insufficient β-globin synthesis results in excessive free α globin, ineffective erythropoiesis, and severe anemia. Fetal hemoglobin (HbF) prevents sickle hemoglobin polymerization; in β thalassemia HbF...

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Share to Hemoglobin structure and function
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35418266
DOI: 10.1080/14728222.2022.2066519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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