Article

Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies

2026-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Sickle cell disease (SCD) is caused by a point mutation in the β-globin gene that promotes hemoglobin polymerization, leading to chronic hemolytic anemia, vaso-occlusive episodes, and progressive organ damage. The most efficacious therapies focus on reactivating fetal hemoglobin (HbF) expression to mitigate the pathological effects of sickle hemoglobin (HbS) polymerization. However, the predomin...

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Literature Corpus work: 0d204e04-a756-5d3a-959d-fd03e1c98adb
DOI: 10.64898/2026.05.18.726003

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