Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

doi:10.1038/jhg.2011.12

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Article

Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.

Journal of human genetics - 1 Apr 2011

Bhatnagar Pallav, Purvis Shirley, Barron-Casella Emily, DeBaun Michael R, Casella James F, Arking Dan E, Keefer Jeffrey R

Abstract excerpt

Fetal hemoglobin (HbF) level has emerged as an important prognostic factor in sickle-cell disease (SCD) and can be measured by the proportion of HbF-containing erythrocytes (F-cells). Recently, BCL11A (zinc-finger protein) was identified as a regulator of HbF, and the strongest association signals were observed either directly for rs766432 or for correlated single-nucleotide polymorphisms (SNPs). To identify...

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PMID: 21326311
DOI: 10.1038/jhg.2011.12
PMCID: PMC5825003

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