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Article

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a

2 Dec 2016

Abstract excerpt

SAMHD1 is a phosphohydrolase maintaining cellular dNTP homeostasis but also acts as a critical regulator in innate immune responses due to its antiviral activity and association with autoimmune disease, leading to aberrant activation of interferon. SAMHD1 expression is differentially regulated by interferon in certain primary cells, but the underlying mechanism is not understood. Here, we report a detailed...

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PMID: 27909056
DOI: 10.1074/jbc.m116.752584

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