Article

Energy expenditure deficits drive obesity in a mouse model of Alström syndrome

2021-12-04

Abstract excerpt

Alström syndrome (AS) is a rare multi-system disorder for which early-onset childhood obesity is a cardinal feature. Like humans with AS, animal models with Alms1 loss-of-function mutations develop obesity, supporting the notion that ALMS1/Alms1 is required for the regulatory control of energy balance across species. This study aimed to determine which component(s) of energy balance are reliant on Alms1. Here, we...

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Literature Corpus work: 6c1bfcdf-670f-53bf-a0e4-299fd13a216d
DOI: 10.1101/2021.12.03.471145

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