Article

Molecular Basis of Inhibitory Mechanism of Naltrexone and Its Metabolites through Structural and Energetic Analyses

2022-06-27

Abstract excerpt

Naltrexone (NTX) is a potent opioid antagonist with good blood-brain barrier permeability, targeting different endogenous opioid receptors, particularly the mu-opioid receptor (MOR). Therefore, it represents a promising candidate for drug development against drug addiction. However, the details of the molecular interactions of NTX and its derivatives with MOR are not fully understood, hindering ligand-based drug d...

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Literature Corpus work: 5d9de76b-7a67-542b-8070-8aa0c687cecb
DOI: 10.20944/preprints202206.0348.v1

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