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Article

Molecular switches of the κ opioid receptor triggered by 6'-GNTI and 5'-GNTI.

Scientific reports - 8 Jan 2016

Cheng Jianxin, Sun Xianqiang, Li Weihua, Liu Guixia, Tu Yaoquan, Tang Yun

Abstract excerpt

The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6'-GNTI was proved to be a G-protein biased agonist, whereas 5'-GNTI acts as an antagonist. To investigate the molecular mechanism of how these two ligands induce different behaviors of the receptor, we built two systems containing the 5'-GNTI-κOR...

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Identifiers

PMID: 26742690
DOI: 10.1038/srep18913
PMCID: PMC4705513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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