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Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

17 Oct 2023

Abstract excerpt

Utilization of human ACE2 allowed several bat coronaviruses (CoVs), including the causative agent of COVID-19, to infect humans directly or via intermediate hosts. However, the determinants of species-specific differences in ACE2 usage and the frequency of the ability of animal CoVs to use human ACE2 are poorly understood. Here we applied VSV pseudoviruses to analyze the ability of Spike proteins from 26 human or...

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PMID: 37848611
DOI: 10.1038/s42003-023-05436-3

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