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<i>Mycobacterium tuberculosis</i> manipulates host inflammation and lipid metabolism through the SET1-interacting protein Rv1075c

2026-08-22

Abstract excerpt

<h4>ABSTRACT</h4> A growing body of literature supports a critical role for nucleomodulins, proteins that traffic to host cell nuclei and manipulate nuclear processes, in intracellular bacterial pathogenesis. Here, we identify the Mycobacterium tuberculosis (Mtb) secreted protein Rv1075c as a nucleomodulin that targets a histone modifying protein complex in macrophages. We report that ΔRv1075c Mtb infection elic...

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Literature Corpus work
5d7e8db2-5395-5d47-b0b3-13c7a4d02942
DOI
10.64898/2026.08.21.746307
Open publication

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<i>Mycobacterium tuberculosis</i> manipulates host inflammation and lipid metabolism through the SET1-interacting protein Rv1075cDOI 10.64898/2026.08.21.746307
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