DNA-RNA hybrid (R-loop): from a unified picture of the mammalian telomere to the genome-wide

Abstract excerpt

<h4>Summary</h4> Local three-stranded DNA-RNA hybrid regions of the genomes (R-loops) have been detected either by binding of a monoclonal antibody (DRIP assay) or by enzymatic recognition by RNaseH. Such a structure has been postulated for the mouse and human telomeres, clearly suggested by the identification of the complementary RNA TERRA. It was, however, evidenced by DRIP exclusively in human cancer and not i...

Topics

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• Advanced biosensing and bioanalysis techniques
• CRISPR and Genetic Engineering
• DNA Repair Mechanisms
• NF-κB Signaling Pathways
• Psoriasis: Treatment and Pathogenesis
• RNA regulation and disease
• RNA Research and Splicing
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

5d669e61-756f-5b75-a4f3-9e93721f5599

DOI

10.1101/2020.08.24.264424