Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA-RNA Hybrid (R-Loop): From a Unified Picture of the Mammalian Telomere to the Genome-Wide Profile

19 Jun 2021

Abstract excerpt

Local three-stranded DNA/RNA hybrid regions of genomes (R-loops) have been detected either by binding of a monoclonal antibody (DRIP assay) or by enzymatic recognition by RNaseH. Such a structure has been postulated for mouse and human telomeres, clearly suggested by the identification of the complementary RNA Telomeric repeat-containing RNA "TERRA". However, the tremendous disparity in the information obtained...

Source

Identifiers

PMID: 34205454
DOI: 10.3390/cells10061556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA-RNA Hybrid (R-Loop): From a Unified Picture of the Mammalian Telomere to the Genome-Wide ProfilePMID 34205454Read ↗

DNA-RNA hybrid (R-loop): from a unified picture of the mammalian telomere to the genome-wideSemantic proximity Read ↗

DNA:RNA hybrids at telomeres – when it is better to be out of the (R) loopSemantic proximity Read ↗

R-Loops at Chromosome Ends: From Formation, Regulation, and Cellular ConsequenceSemantic proximity Read ↗

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integritySemantic proximity Read ↗

TERRA and the alternative lengthening of telomeres: a dangerous affairSemantic proximity Read ↗

Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops.Semantic proximity Read ↗

Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbingSemantic proximity Read ↗

Telomere elongation chooses TERRA ALTernativesSemantic proximity Read ↗

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instabilitySemantic proximity Read ↗

In Vitro Characterization of the Physical Interactions between the Long Noncoding RNA TERRA and the Telomeric Proteins TRF1 and TRF2Semantic proximity Read ↗

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA DamageSemantic proximity Read ↗

The RNA-binding motif protein 14 regulates telomere integrity at the interface of TERRA and telomeric R-loopsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.