Article

Machine Learning-Based Prediction of Cell-type Resolved Brain eQTLs Enhances Discovery of Variants Explaining Alzheimer’s Disease Heritability

2025-12-04

Abstract excerpt

The majority of causal genome-wide association studies (GWAS) variants for Alzheimer’s disease (AD) are believed to reside in noncoding regions of the genome, where they likely affect gene regulation, particularly in microglia. Although expression Quantitative Trait Loci (eQTL) studies offer valuable insights into gene regulation, they tend to identify variants in the promoter regions of genes under weaker selecti...

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Literature Corpus work: 5d648864-f19b-5737-a466-6fedf1eb1afc
DOI: 10.64898/2025.12.03.25341562

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