Article

Structural Capacitance in Protein Evolution and Human Diseases

2018-02-22

Abstract excerpt

Canonical mechanisms of protein evolution include the duplication and diversification of pre-existing folds through genetic alterations that include point mutations, insertions, deletions, and copy number amplifications, as well as post-translational modifications that modify processes such as folding efficiency and cellular localization. Following a survey of the human mutation database, we have identified an add...

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Literature Corpus work: 3a1c6471-908a-53d7-8089-97b30450d900
DOI: 10.1101/269613

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