Article

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

2021-03-30

Abstract excerpt

<h4> A bstract </h4> <h4>Background</h4> Intratumoural heterogeneity is a poor prognostic feature in triple-negative breast cancer (TNBC) and other high-grade malignancies. It is caused by genomic instability and phenotypic plasticity, but how these features co-evolve during tumour development remains unclear. SOX10 is a transcription factor, neural crest stem cell (NCSC) specifier and candidate mediator of ca...

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Literature Corpus work: 5d3011a6-584e-5a93-9821-17d179166c9d
DOI: 10.1101/2021.03.30.437624

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