Article

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations

2022-11-23

Abstract excerpt

Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we employ female human embryonic stem cell (hESC) differentiation and single-cell transcriptome and epigenome analysis to assess the effects of chromosome 17q/1q gains, which are prev...

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Literature Corpus work: 3ddf0180-1e56-5dd7-9904-02b96b64f1a4
DOI: 10.1101/2022.11.21.515753

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