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Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

2 May 2022

Abstract excerpt

Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but how these features co-evolve remains unclear. SOX10 is a neural crest stem cell (NCSC) specifier and candidate mediator of phenotypic plasticity in cancer. We investigated its relevance in breast cancer by immunophenotyping 21 normal breast and 1860 tumour samples. Nuclear SOX10 was detected in normal mammary luminal...

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PMID: 35501337
DOI: 10.1038/s41523-022-00425-x

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