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A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations

3 May 2024

Abstract excerpt

Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we employ female human embryonic stem cell (hESC) differentiation and single-cell transcriptome and epigenome analysis to assess the effects of chromosome 17q/1q gains, which are...

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PMID: 38702304
DOI: 10.1038/s41467-024-47945-7

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