Article

Ensemble of Nucleic Acid Absolute Quantitation Modules for Accurate Copy Number Variation Detection and Targeted RNA Profiling

2021-09-28

Abstract excerpt

<title>Abstract</title> <p>Current gold standard for absolute quantitation of a specific DNA sequence is droplet digital PCR (ddPCR), which has been applied to gene copy number variation (CNV) detection. However, the number of quantitation modules in ddPCR has been limited by fluorescence channels, which thus limits the CNV sensitivity due to sampling error following Poisson distribution. Here we develop a PCR-ba...

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Literature Corpus work: 5ce4b51b-2422-503f-ad1e-36f881c54d09
DOI: 10.21203/rs.3.rs-923491/v1

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