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Detection and quantification of integrated vector copy number by multiplex droplet digital PCR in dual-transduced CAR T cells

15 Jul 2023

Abstract excerpt

The success of chimeric antigen receptor (CAR) T cell therapies in refractory hematologic malignancies has prompted investigation of their efficacy in solid tumors. AUTO6NG is a dual-transduced GD2-targeting CAR that encodes distinct modules designed to enhance T cell activity in relapsed/refractory neuroblastoma. The ability to detect and precisely quantify vector copy number (VCN) for each integrated vector is...

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PMID: 37622159
DOI: 10.1016/j.omtm.2023.07.003

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