Article

Investigation of the activation mechanism and structural characterization of the CGRP receptor

2013-01-01

Abstract excerpt

The calcitonin gene-related peptide (CGRP) receptor is an unusual G protein-coupled receptor (GPCR) in that it comprises the calcitonin receptor-like receptor (CLR), receptor activity modifying protein 1 (RAMP1) and the receptor component protein (RCP). The RAMP1 has two other homologues – RAMP2 and RAMP3. The endogenous ligand for this receptor is CGRP, a 37 amino acid neuropeptide that act as a vasodilator. This...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0616d500-517e-520f-be23-7dacfa90ebb2
DOI: 10.48780/publications.aston.ac.uk.00020905

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigation of the activation mechanism and structural characterization of the CGRP receptorDOI 10.48780/publications.aston.ac.uk.00020905Read

An insight into the activation mechanism of the calcitonin-gene-related peptide receptorSemantic proximity Read

Molecular simulations reveal the impact of RAMP1 on ligand binding and dynamics of CGRPR heterodimerSemantic proximity Read

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.Semantic proximity Read

CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cellsSemantic proximity Read

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.Semantic proximity Read

The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function.Semantic proximity Read

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-levelSemantic proximity Read

Epigenetic Connection of the Calcitonin Gene-Related Peptide and Its Potential in MigraineSemantic proximity Read

Association study of the calcitonin gene-related polypeptide-alpha (CALCA) and the receptor activity modifying 1 (RAMP1) genes with migraine.Semantic proximity Read

Atogepant: Mechanism of action, clinical and translational scienceSemantic proximity Read

Receptor activity modifying proteins.Semantic proximity Read

Circulating levels of calcitonin gene-related peptide (CGRP) are lower in COVID-19 patientsSemantic proximity Read