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Article

The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function.

The Journal of biological chemistry - 18 Apr 2003

Fitzsimmons Timothy J, Zhao Xilin, Wank Stephen A

Abstract excerpt

A functional calcitonin gene-related peptide (CGRP) receptor requires dimerization of calcitonin receptor-like receptor (CRLR) with receptor activity-modifying protein 1 (RAMP 1). To determine the function of the three domains (extracellular, ECD; transmembrane, TM; and tail domains) of human RAMP 1, three mutants were constructed: RAMP 1 without the cytoplasmic tail, a chimera consisting of the ECD of RAMP 1 and...

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PMID: 12574158
DOI: 10.1074/jbc.M211946200

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ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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