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Article

Repeated Episodes of GPP Induced by Respiratory Infections Are Mediated by Loss-of-Function IFIH1.

Immunity, inflammation and disease - 1 Mar 2026

Liu Yaqin, Sun Yanan, Yang Juan, Li Hongmei, Zhou Weihui, Meng Shasha

Abstract excerpt

BACKGROUND: Generalized pustular psoriasis (GPP) is a severe and recurrent autoinflammatory disease that can be induced by a variety of factors. At present, its etiology and pathogenesis have not yet been fully elucidated. Upper respiratory tract infections are the main predisposing factor in children with GPP, and the MDA5 protein encoded by the IFIH1, functions as a key receptor for sensing upper respiratory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-Induced Helicase, IFIH1

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Source

Open in PubMed Open full text

Identifiers

PMID: 41847945
DOI: 10.1002/iid3.70397
PMCID: PMC13097489

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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