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Article

MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients.

Clinical reviews in allergy & immunology - 1 Dec 2024

Maiti Amit K

Abstract excerpt

Apart from the skin and mucosal immune barrier, the first line of defense of the human immune system includes MDA5 (ifih1 gene) which acts as a cellular sensor protein for certain viruses including SARS-CoV-2. Upon binding with viral RNA, MDA5 activates cell-intrinsic innate immunity, humoral responses, and MAVS (mitochondrial antiviral signaling). MAVS signaling induces type I and III interferon (IFN)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39460899
DOI: 10.1007/s12016-024-09008-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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