Severe viral respiratory infections in children with IFIH1 loss-of-function mutations.

doi:10.1073/pnas.1704259114

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Article

Severe viral respiratory infections in children with IFIH1 loss-of-function mutations.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2017

Asgari Samira, Schlapbach Luregn J, Anchisi Stéphanie, Hammer Christian, Bartha Istvan, Junier Thomas, Mottet-Osman Geneviève, Posfay-Barbe Klara M, Longchamp David, Stocker Martin, Cordey Samuel, Kaiser Laurent, Riedel Thomas, Kenna Tony, Long Deborah, Schibler Andreas, Telenti Amalio, Tapparel Caroline, McLaren Paul J, Garcin Dominique, Fellay Jacques

Abstract excerpt

Viral respiratory infections are usually mild and self-limiting; still they exceptionally result in life-threatening infections in previously healthy children. To investigate a potential genetic cause, we recruited 120 previously healthy children requiring support in intensive care because of a severe illness caused by a respiratory virus. Using exome and transcriptome sequencing, we identified and characterized...

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Identifiers

PMID: 28716935
DOI: 10.1073/pnas.1704259114
PMCID: PMC5547624

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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