Article

Immunoglobulins are rapidly internalized by neurons after CNS injury and cleared through lysosomal degradation

2026-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Spinal cord injury (SCI) causes hemorrhage and blood-spinal cord barrier disruption, allowing blood-derived molecules to infiltrate the parenchyma. While immunoglobulins (Ig) are abundant plasma proteins, their distribution and cellular targets within the injured spinal cord remain poorly defined. Here, we show that circulating non-autoimmune immunoglobulins rapidly infiltrate the spinal cord af...

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Literature Corpus work: 5caa5d7e-0e8c-53a6-8b37-638a29557d8a
DOI: 10.64898/2026.07.16.738985

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