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Article

Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2011

Wang Chun-Yan, Zheng Wei, Wang Tao, Xie Jing-Wei, Wang Si-Ling, Zhao Bao-Lu, Teng Wei-Ping, Wang Zhan-You

Abstract excerpt

Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer's disease (AD) therapy. In this study, we searched for new mechanisms by which HupA could activate Wnt signaling and reduce amyloidosis in AD brain. A nasal gel containing HupA was prepared. No obvious toxicity of intranasal administration of HupA was found in mice. HupA...

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Identifiers

PMID: 21289607
DOI: 10.1038/npp.2010.245
PMCID: PMC3077275

Genes

APP
ADAM10
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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